SMALP User Meeting 2019
MBB organizes the next annual SMALP User Meeting that will be held in Utrecht on Friday April 26, 2019. We will discuss the latest developments in polymer chemistry, methods and applications of SMA copolymers in membrane biology, biophysics and structural biology and we will explore new alternatives for SMA.
Workshops will be offered to a limited number of participants in the MBB laboratory on Thursday 25th and on Monday 29th of April, to learn more about SMALPing and native nanodiscs.
SMALP User Meeting Website
Welcome to students Federico Antoniciello , Suzan Rinia and Fabrice Gilissen on February 4th 2019
Master student Federico will be supervised by Adrian Kopf and his research subject is "Biological membrane solubilization by SMA copolymers".
Trainee technician Suzan started her research under supervision of Martijn Koorengevel to do research about "SMA concentrations".
Master student Fabrice will be supervised by Eefjan Breukink in the "Plasma research project".
The strategic Alliance between Eindhoven University of Technology, Utrecht University and UMC Utrecht has funded a multidisciplinary research program involving the generation and application of non-thermal plasmas to combat bacterial infections and cancer. Within MBB the molecular mechanisms underlying the bactericidal and tumoricidal activity of cold atmospheric plasmas will be investigated with a special focus on the role of membranes. (June 2018)
Welcome to research technician Eveline Koch
On November 1st 2018, Eveline started at MBB as research technician for the plasma project.
Eefjan Breukink co-published Nature Communications article
For the first time, researchers have been able to observe the mode of action of a promising class of alternative antibiotics directly in bacterial cellular membranes. Until now, such studies could only be done in less relevant media, such as organic solvents or micelles. The approach developed could provide important clues to design drugs for combatting drug-resistant bacteria. Their findings already suggest novel clues to improve the activity of nisin, the most popular antibiotic of this class. The study, led by Markus Weingarth (NMR) and Eefjan Breukink (MBB), is published in Nature Communications.
Welcome to PhD candidate Min Xie
On October 1st 2018, Min started her PhD research under supervision of Antoinette Killian in the plasma project.
NWO-ECHO grant for Eefjan Breukink
Eefjan Breukink has received a NWO-ECHO grant together with NMR colleague Markus Weingarth to study the “high resolution structures of novel antibiotics in their natural environment in order to overcome antibacterial resistance”. They will study the mode of action of novel antibiotics in their natural environment: the bacterial target membrane. For this they will use state of the art NMR technology available in the Bijvoet center. (May 2018)
FEBS Summer Fellowship Grant for Mike Renne
In May 2018, Mike was awarded a FEBS Summer Fellowship, which he will use to visit the lab of Dr. Christer Ejsing at the University of Southern Denmark. Mike will be trained in high resolution mass spectrometry techniques and data processing for lipidomics and work on a collaborative project to quantify the fluxes through PE and PC lipid biosynthetic pathways in yeast.
MBB moved to 8th floor of Kruyt building
The Membrane Biochemistry & Biophysics research group and lab successfuly moved within the Kuyt Building. From now on, you can find us in the South wing of the 8th floor at the Padualaan 8 in Utrecht.
Xue Bao PhD thesis defense
On Wednesday March 28th 2018, Xue successfully defended her PhD thesis with the title: "Characterization of Saccharomyces cerevisiae suppressor mutants devoid of the membrane lipid phosphatidylcholine".
Juan Dominguez Pardo defended his PhD thesis
On Monday March 19th 2018, Juan successfully defended his PhD thesis with the title: "Insights into membrane solubilization by styrene-maleic acid copolymers".
Bacterial Cell Envelope Meeting organized by Eefjan Breukink
On Thursday March 15th and Friday March 16th 2018, Eefjan Breukink organized the Bacterial Cell Envelope Meeting in Utrecht. Staff and PhD candidates from the universities of Amsterdam, Groningen, Leiden and Utrecht gave lectures and participated in the meeting.
NWO-ECHO grant awarded to Toon de Kroon
On December 20th 2017, Toon received an ECHO grant from ENW-NWO to investigate the mechanism that allows a yeast suppressor mutant to survive without the abundant and essential membrane lipid phosphatidylcholine.
Sabine Oppedijk defended PhD thesis
On Wednesday October 25th 2017, Sabine Oppedijk succesfully defended her PhD thesis with the title: "Identification, purification and elucidation of the mode of action of (novel) antimicrobial substances".
Welcome to PhD candidate Adrian Kopf
Adrian Kopf started his PhD reserach on synthetic polymers that can solubilize membranes in the form of nanodisks per October 1st 2017.
Presentation Prize Mike Renne
PhD candidate Mike Renne has won the prize for best presentation at the Science4Life conference on 25 September 2017 with the title "Crosstalk between membrane lipid unsaturation and inter-organelle lipid transport".
NWO-ECHO grant for Antoinette Killian
Antoinette Killian has been awarded with a NWO ECHO grant for research on synthetic polymers that can solubilize membranes in the form of nanodisks.
FEBS EMBO Lecture Course by Eefjan Breukink
Eefjan Breukink Eefjan Breukink succesfully organized the FEBS-EMBO lecture course on "Molecular Architecture, Dynamics and Function of Biomembranes" from June 12th till June 21st 2017 at Cargèse Corsica. You can read more about the course at this webpage.
Kees van Walree in the media
Kees van Walree did research for the Dutch television program Radar about the placebo effect of `irradiated water` that bio energetic therapists sell to their clients. Video from minute 12:37.
PhD Defense for Jonas Dörr
Jonas Dörr succesfully defended his thesis on Wednesday the 22nd of March 2017 at the University Utrecht. His thesis is titled: `Membrane solubilization by styrene-maleic acid copolymers: towards new applications in membrane protein research.
Cover picture of recent paper by Inge van't Veer
The inside cover picture shows a schematic representation of the creation of a protein with a site specifically incorporated unnatural amino acid containing an azide functionality by using nonsense suppression mutagenesis. For this work Inge won the poster price at a recent Bijvoet Symposium.
-cf E. Breukink et al. (DOI: 10.1002/cbic.201600461).
Phd Defense for Stefan Scheidelaar
We congratulate Stefan Scheidelaar, who defended his thesis succesfully on Wednesday the 26th of October 2016 at the University Utrecht. His thesis was titled: Solubilization of lipids and membrane proteins into nanodiscs. Mode of action and applications of SMA copolymers.
Yang Xu started in our group
We welcome Yang Xu to our group as a new CSS grant student. He will be working under the supervision of Eefjan Breukink on the topic of antibacterial compounds that act specifically at the outer membrane of Gram-negative bacteria.
We congratulate Yao Liu, who defended her thesis succesfully on Monday 30th of May at the University Utrecht
Thesis title: 'Towards novel antibacterial development – from peptidoglycan to lipoprotein biogenesis'
Joost Ballering successfully defended his thesis in the Academiegebouw of the University Utrecht.
Title thesis: 'Molecular insights into the mechanism of sensing and signal transduction of the thermosensor DesK'
Eefjan Breukink is featuring in a article of C2W life science and Medicines
In C2W life sciences edition 5 (18 March 2016) and Medicines edition 1 (February 2016), Eefjan Breukink is featuring in an article: The Achilles heel of the cell membrane of bacteria , written by Tim Vernimmen. In these articles Eefjan explains what the benefits are for exploring and understanding the workings of the cel membranes of the bacteria; for instance in the discovery of new antibiotics.
Inge van 't Veer defended her thesis succesfully on Wednesday 16th of March 2016 in the 'Academiegebouw' at Utrecht
Title thesis: 'Peptidoglycan synthesis in Escherichia coli from a PBP1b perspective'