Membranes and Beyond
Biological membranes form the barriers which separate inside from outside in biological systems. They consist of a bilayer, built up of many different lipids, in which proteins are embedded. These proteins are responsible for many specific functions of membranes. Interactions between these proteins and lipids are of key essence for membrane biogenesis, membrane organization and membrane function, but they are also major factors in the mode of action of polypeptide toxins, antibiotics and amyloid forming proteins. Our focus lies on these membranes in the hope with better understanding we can have better inside in membrane related diseases and create new ways for more effective drugs.
Antoinette Killian main focus is on the role of lipid modulation on membrane protein within the cell.
Eefjan Breukink is involved in the work bacterial cell membranes and the pursuit for novel ways of antibiotics targets.
Toon de Kroon
Toon de Kroon's research focusses on membrane lipid homeostasis in the reference eukaryote Saccharomyces cerevisiae.
Understanding enzyme action is the main research interest of Maarten Egmond.